[HTML][HTML] In vivo and in vitro models to study liver fibrosis: mechanisms and limitations
YS Lee, E Seki - Cellular and Molecular Gastroenterology and …, 2023 - Elsevier
Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver
diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying …
diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying …
[HTML][HTML] Culture of vibrating microtome tissue slices as a 3D model in biomedical research
F Siwczak, C Hiller, H Pfannkuche… - Journal of biological …, 2023 - Springer
The basic idea behind the use of 3-dimensional (3D) tools in biomedical research is the
assumption that the structures under study will perform at the best in vitro if cultivated in an …
assumption that the structures under study will perform at the best in vitro if cultivated in an …
[HTML][HTML] Modeling nonalcoholic fatty liver disease in the dish using human-specific platforms: strategies and limitations
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting multiple cell
types of the human liver. The high prevalence of NAFLD and the lack of approved therapies …
types of the human liver. The high prevalence of NAFLD and the lack of approved therapies …
[HTML][HTML] Human precision-cut liver slices: A potential platform to study alcohol-related liver disease
U Rastovic, SF Bozzano, A Riva… - International Journal of …, 2023 - mdpi.com
Alcohol-related liver disease (ALD) encompasses a range of pathological conditions that are
complex to study at the clinical and preclinical levels. Despite the global burden of ALD …
complex to study at the clinical and preclinical levels. Despite the global burden of ALD …
[HTML][HTML] Analysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic rats
Precision-cut liver slices (PCLS) are increasingly used as a model to investigate anti-fibrotic
therapies. However, many studies use PCLS from healthy animals treated with pro-fibrotic …
therapies. However, many studies use PCLS from healthy animals treated with pro-fibrotic …
[HTML][HTML] Precision-Cut Liver Slices as an ex vivo model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis
Background: Precision-Cut Liver Slices (PCLS) are an ex vivo culture model developed to
study hepatic drug metabolism. One of the main benefits of this model is that it retains the …
study hepatic drug metabolism. One of the main benefits of this model is that it retains the …
[HTML][HTML] Orphan receptor GPR176 in hepatic stellate cells exerts a profibrotic role in chronic liver disease
Abstract Background & Aims Chronic liver disease (CLD) remains a global health issue
associated with a significant disease burden. Liver fibrosis, a hallmark of CLD, is …
associated with a significant disease burden. Liver fibrosis, a hallmark of CLD, is …
[HTML][HTML] Experimental Models for Studying Structural and Functional State of the Pathological Liver
DP Krylov, SA Rodimova, MM Karabut… - Современные …, 2023 - cyberleninka.ru
Liver pathologies remain one of the leading causes of mortality worldwide. Despite a high
prevalence of liver diseases, the possibilities of diagnosing, prognosing, and treating non …
prevalence of liver diseases, the possibilities of diagnosing, prognosing, and treating non …
Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production
B Bakker, LA Kiyuna, KA Krishnamurthy… - 2023 - researchsquare.com
Fasting hypoglycemia is a severe and incompletely understood symptom of various inborn
errors of metabolism (IEM). Precision-cut liver slices (PCLS) represent a promising model to …
errors of metabolism (IEM). Precision-cut liver slices (PCLS) represent a promising model to …