Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …

Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …

Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

The triple-angiokinase inhibitor nintedanib is an orally available, potent, and selective
inhibitor of tumor angiogenesis by blocking the tyrosine kinase activities of vascular …

The clinical success of polypeptides as polymeric drugs, covered by the umbrella term
“polymer therapeutics,” combined with related scientific and technological breakthroughs …

The penetration of anticancer drugs in solid tumors is important to ensure the therapeutic
effect, so methods are needed to understand drug distribution in different parts of the tumor …

Background Scarce drug penetration in solid tumours is one of the possible causes of the
limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The …

Abstract Mass Spectrometry Imaging (MSI) is a widespread technique used to qualitatively
describe in two dimensions the distribution of endogenous or exogenous compounds within …

Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the
antitumor and antivascular properties of five different antiangiogenic receptor tyrosine …

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass
spectrometry (IMS) enables localization of analytes of interest along with histology. More …