Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Traumatic brain injury (TBI) is a major public health challenge that is also the third leading
cause of death worldwide. It is also the leading cause of long-term disability in children and …

The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular
endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB …

Brain renin‐angiotensin (Ang) system (RAS) is implicated in neuroinflammation, a major
characteristic of aging process. Angiotensin (Ang) II, produced by angiotensin‐converting …

Recent studies from our group and others have demonstrated that oxidative stress, Ca 2+
signaling, and neuroinflammation are major mechanisms contributing to post-traumatic …

Growing evidence implicates the renin–angiotensin system (RAS) in multiple facets of
neuropathic pain (NP). This narrative review focuses primarily on the major bioactive RAS …

There is considerable interest in traumatic brain injury (TBI) induced by repeated
concussions suffered by athletes in sports, military personnel from combat-and non-combat …

In this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related
factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of a brain injury. To …

Brain insulin signaling is accounted for the development of a variety of neuropsychiatric
disorders, such as anxiety and depression, whereas both inflammation and the activated …

Mitogen-activated protein (MAP) kinases are serine/threonine protein kinases that play a
critical role in signal transduction and are activated by phosphorylation in response to a …