Complement system and potential therapeutics in age-related macular degeneration
YG Park, YS Park, IB Kim - International Journal of Molecular Sciences, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a complex multifactorial disease characterized
in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment …
in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment …
Complement system and age‐related macular degeneration: implications of gene‐environment interaction for preventive and personalized medicine
A Maugeri, M Barchitta, MG Mazzone… - BioMed research …, 2018 - Wiley Online Library
Age‐related macular degeneration (AMD) is the most common cause of visual loss in
developed countries, with a significant economic and social burden on public health …
developed countries, with a significant economic and social burden on public health …
Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration
DC Zysset-Burri, I Keller, LE Berger… - NPJ genomic …, 2020 - nature.com
Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the
aged population. The etiology of AMD is multifactorial including nutritional factors, genetic …
aged population. The etiology of AMD is multifactorial including nutritional factors, genetic …
Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study
C Törn, X Liu, W Hagopian, Å Lernmark, O Simell… - Scientific reports, 2016 - nature.com
A total of 15 SNPs within complement genes and present on the ImmunoChip were
analyzed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A …
analyzed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A …
Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis
J Zhang, S Li, S Hu, J Yu, Y Xiang - BMC ophthalmology, 2018 - Springer
Background The purpose of this study is to discuss whether genetic variants (rs2230199,
rs1047286, rs2230205, and rs2250656) in the C3 gene account for a significant risk of …
rs1047286, rs2230205, and rs2250656) in the C3 gene account for a significant risk of …
An association of neovascular age‐related macular degeneration with polymorphisms of CFH, ARMS2, HTRA1 and C3 genes in Czech population
V Matušková, T Zeman, L Ewerlingová… - Acta …, 2020 - Wiley Online Library
Purpose We investigated associations between neovascular age‐related macular
degeneration (AMD) and rs10490924 polymorphism of ARMS2 gene (age‐related …
degeneration (AMD) and rs10490924 polymorphism of ARMS2 gene (age‐related …
The role of the microbiome in age-related macular degeneration: a review of the literature
A Zisimopoulos, O Klavdianou, P Theodossiadis… - …, 2021 - karger.com
Background: Age-related macular degeneration (AMD) is a progressive, multifactorial,
degenerative disease and the leading cause of severe visual loss in the elderly population …
degenerative disease and the leading cause of severe visual loss in the elderly population …
Association of genetic variants rs641153 (CFB), rs2230199 (C3), and rs1410996 (CFH) with age-related macular degeneration in a Brazilian population
JM Neto, MGM Viturino, G Ananina… - Experimental …, 2021 - journals.sagepub.com
This study aimed to investigate the association among genetic variants of the complement
pathway CFB R32Q (rs641153), C3 R102G (rs2230199), and CFH (rs1410996) with age …
pathway CFB R32Q (rs641153), C3 R102G (rs2230199), and CFH (rs1410996) with age …
C3 Gene Functional Polymorphisms and C3 Serum Levels in Patients with Rheumatoid Arthritis
L Sena, CF Oliveira-Toré, T Skare… - Immunological …, 2021 - Taylor & Francis
The complement system is a key component of the innate immunity that plays a significant
role in the development and clinical presentation of Rheumatoid arthritis (RA). Complement …
role in the development and clinical presentation of Rheumatoid arthritis (RA). Complement …
Genetics of large pigment epithelial detachments in neovascular age-related macular degeneration
A Mouallem-Beziere, R Blanco-Garavito, F Richard… - Retina, 2020 - journals.lww.com
Purpose: We hypothesized that severe forms of neovascular age-related macular
degeneration (AMD) such as large pigment epithelial detachments poorly responding to anti …
degeneration (AMD) such as large pigment epithelial detachments poorly responding to anti …