Severe COVID-19 patients show various immunological abnormalities including T-cell
reduction and cytokine release syndrome, which can be fatal and is a major concern of the …

Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have been
implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s …

Cancer cells are under the surveillance of the host immune system. Nevertheless, a number
of immunosuppressive mechanisms allow tumors to escape protective responses and …

Abstract Purpose of Review Aging leads to decline in bone mass and quality starting at age
30 in humans. All mammals undergo a basal age-dependent decline in bone mass …

Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat
detrimental inflammatory conditions after transplantation and during autoimmune disease …

Metazoa gene expression is controlled by modular DNA segments called cis-regulatory
modules (CRMs). CRMs can convey promoter/enhancer/insulator roles, generating …

In acute myeloid leukemia (AML), leukemia stem cells (LSCs) and leukemia progenitor cells
(LPCs) interact with various cell types in the bone marrow (BM) microenvironment …

The changes to the epigenetic landscape in response to Ag during CD4 T cell activation
have not been well characterized. Although CD4 T cell subsets have been mapped globally …

Inferring the driving regulatory programs from comparative analysis of gene expression data
is a cornerstone of systems biology. Many computational frameworks were developed to …

Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks
associated with the development of therapies from manipulated human cells are …