Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …

This article reviews various procedures used in the analysis of circadian rhythms at the
populational, organismal, cellular and molecular levels. The procedures range from visual …

Time of day-dependent variations of immune system parameters are ubiquitous phenomena
in immunology. The circadian clock has been attributed with coordinating these variations …

Circadian rhythms govern a large array of metabolic and physiological functions. The central
clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its …

Circadian rhythms result from feedback loops involving clock genes and their protein
products. In mammals, 2 orphan nuclear receptors, REV-ERBα and RORα, play important …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

Abstract The PAS (PER-ARNT-SIM) helix-loop-helix transcription factor BMAL1 (also known
as MOP3) is an essential component of the circadian pacemaker in mammals. Here we …

Organisms adapt to day–night cycles through highly specialized circadian machinery,
whose molecular components anticipate and drive changes in organism behavior and …

The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …

Circadian rhythms are endogenous oscillations of physiological and behavioral phenomena
with period length of∼ 24 hr. A mutation in human Period 2 (hPER2), a gene crucial for …