More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Abstract N 6-methyladenosine (m6A) has been identified as the most abundant modification
on eukaryote messenger RNA (mRNA). Although the rapid development of high-throughput …

In order to localize the neural circuits involved in generating behaviors, it is necessary to
assign activity onto anatomical maps of the nervous system. Using brain registration across …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this
regenerative response are Müller glia that respond to retinal injury by undergoing a …

Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …

The ability to visualize and quantitatively measure dynamic biological processes in vivo and
at high spatiotemporal resolution is of fundamental importance to experimental …

Left ventricular noncompaction (LVNC) causes prominent ventricular trabeculations and
reduces cardiac systolic function. The clinical presentation of LVNC ranges from …

Within the circulatory system, blood flow regulates vascular remodelling, stimulates blood
stem cell formation, and has a role in the pathology of vascular disease. During vertebrate …