Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal
barrier disruption. The STING signaling is associated with gut homeostasis and barrier …

Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

BACKGROUND. Acute respiratory distress syndrome (ARDS) is a prevalent disease with
significant mortality for which no effective pharmacologic therapy exists. Low-dose inhaled …

Background Sepsis is a heterogeneous syndrome, and the identification of clinical
subphenotypes is essential. Although organ dysfunction is a defining element of sepsis …

Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered
attention for its role in various pathological conditions. While initially recognized for its …

Vascular injury is a well-established, disease-modifying factor in acute respiratory distress
syndrome (ARDS) pathogenesis. Recently, coronavirus disease 2019 (COVID-19)–induced …

The role of high-mobility group box-1 (HMGB1) in outcome prediction in sepsis is
controversial. Furthermore, its association with necroptosis, a programmed cell necrosis …