Aortic valve stenosis due to calcification of the valve leaflets is the most common valve
disease in the developed world. It is the third leading cause of cardiovascular disease. 1 …

Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …

Objective—Extensive remodeling of the valve ECM in calcific aortic valve sclerosis alters its
mechanical properties, but little is known about the impact of matrix mechanics on the cells …

Vascular calcification is associated with atherosclerosis, chronic kidney disease, and
diabetes, and results from processes resembling endochondral or intramembranous …

Kawasaki disease (KD) is a medium vessel vasculitis that affects young children. Despite
extensive research over the last 50 years, the etiology of KD remains an enigma. Seasonal …

Objective—Hemodynamics has been associated with aortic valve (AV) inflammation, but the
underlying mechanisms are not well understood. Here we tested the hypothesis that altered …

Cardiac valves function in a mechanically complex environment, opening and closing close
to a billion times during the average human lifetime, experiencing transvalvular pressures …

Advanced valvular lesions often contain ectopic mesenchymal tissues, which may be
elaborated by an unidentified multipotent progenitor subpopulation within the valve …

Transforming growth factor β (TGFβ) family members are involved in a wide range of diverse
functions and play key roles in embryogenesis, development and tissue homeostasis …

Calcific aortic valve disease (CAVD), previously thought to represent a passive
degeneration of the valvular extracellular matrix (VECM), is now regarded as an intricate …