Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances and other
symptoms, and has a substantial socioeconomic impact. Current biomedical and …

Abstract Purpose of Review Patients with chronic pain, especially primary or centralized
pain, have elevated rates of psychosocial trauma and intrapersonal or intrapsychic conflict …

Objective Multiple and specific types of childhood adverse events are risk factors for chronic
pain conditions. Although both can covary, no study has evaluated one aspect while …

Objective Chronic pain is a significant health problem that is increasing in prevalence, and
advances in treatment are needed. Methods We briefly review the leading evidence-based …

Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia
has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail …

There is growing interest in psychosocial trauma and chronic pain (CP). Numerous
retrospective studies link trauma or posttraumatic stress disorder (PTSD) to CP, 6–9, 12, 35 …

Objective To conduct a comprehensive search for evidence with regard to whether central
sensitization after an injury can act as a persistent autonomous pain generator after the …

Pain remains one of the most common and costly health conditions in the developed world,
and sex and gender differences in the experience of pain are well-documented …

Background Early adversity predisposes to chronic pain, but a mechanistic explanation is
lacking. Survivors of early adversity with chronic pain often seem impaired in their ability to …

Exposure to adverse experiences is a well‐established major risk factor for affective
psychopathology. The vulnerability of deleterious sequelae is assumed in maladaptive …