The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Figure. Cerebral aneurysm (CA) formation and rupture. Aneurysm formation is initiated by
hemodynamically triggered endothelial dysfunction. An inflammatory response implicating …

Background and Purpose—Discrimination of the stability of intracranial aneurysms is critical
for determining the treatment strategy, especially in small aneurysms. This study aims to …

Cerebral aneurysms (CAs) are characterized by a pathological wall structure with internal
elastic lamina and media disruption, which leads to focal weakened pouches of the arterial …

Unruptured intracranial aneurysm (UIA) is a life-threatening cerebrovascular condition.
Whether changes in gut microbial composition participate in the development of UIAs …

Background There seems to be a pathogenetic link between hemodynamics and
inflammatory arterial wall alteration leading to the development and rupture of intracranial …

Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …

Vascular smooth muscle cells (SMC) maintain significant plasticity. Following environmental
stimulation, SMC can alter their phenotype from one primarily concerned with contraction to …

Cardiovascular diseases (CVDs) are major causes of death worldwide. Identification of
promising targets for prevention and treatment of CVDs is paramount in the cardiovascular …

Rationale: Although not fully understood, the phenotypic transition of vascular smooth
muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the …