Cleft of the lip with or without cleft palate (CL/P) represents one of the commonest congenital
malformations in Western countries. Based on their association with specific malformative …

The ubiquitous nature of micro-(MP) and nanoplastics (NP) is a growing environmental
concern. However, their potential impact on human health remains unknown. Research …

Orofacial clefting is a common birth defect with significant morbidity. A panoply of candidate
genes have been discovered through synergy of animal models and human genetics …

Purpose: Mutations in the transcription factor IRF6 cause allelic autosomal dominant clefting
syndromes, Van der Woude syndrome, and popliteal pterygium syndrome. We compared …

Nonsyndromic cleft lip with or without cleft palate (NSCL/P) are common birth defects with a
complex etiology. Multiple interacting loci and possible environmental factors influence the …

Background Orofacial clefts are congenital malformations of the orofacial region, with a
global incidence of one per 700 live births. Interferon Regulatory Factor 6 (IRF 6)(OMIM …

Objective: The etiology of oral clefts in humans is genetically complex and mutations in
multiple genes have been linked with clefting. CDH1 (E-cadherin) has been found to be …

The role of interferon regulatory factor 6 (IRF6) gene mutations in causing Van der Woude
syndrome (VWS) and poplyteal pterygium syndrome has been described in different …

Orofacial clefts (OFCs), including cleft lip (CL), cleft palate (CP), and cleft lip and palate
(CLP), are one of the most common birth defects with an estimated prevalence of 1: 1000 …

Non-syndromic oral clefts comprising cleft lip with and without cleft palate (CL/P) and cleft
palate only (CPO) are common birth defects worldwide. Their aetiology involves both …