Spike sorting: new trends and challenges of the era of high-density probes

AP Buccino, S Garcia, P Yger - Progress in Biomedical …, 2022 - iopscience.iop.org
Recording from a large neuronal population of neurons is a crucial challenge to unravel how
information is processed by the brain. In this review, we highlight the recent advances made …

From end to end: Gaining, sorting, and employing high-density neural single unit recordings

RB Bod, J Rokai, D Meszéna, R Fiáth… - Frontiers in …, 2022 - frontiersin.org
The meaning behind neural single unit activity has constantly been a challenge, so it will
persist in the foreseeable future. As one of the most sourced strategies, detecting neural …

Synchronous spiking of cerebellar Purkinje cells during control of movements

E Sedaghat-Nejad, JS Pi, P Hage… - Proceedings of the …, 2022 - National Acad Sciences
The ability of the brain to accurately control a movement depends on the cerebellum. Yet,
how the cerebellar neurons encode information relevant for this control remains poorly …

Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

EK Lee, H Balasubramanian, A Tsolias, SU Anakwe… - Elife, 2021 - elifesciences.org
Cortical circuits are thought to contain a large number of cell types that coordinate to
produce behavior. Current in vivo methods rely on clustering of specified features of …

Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice

MA Gaffield, BA Sauerbrei, JM Christie - Elife, 2022 - elifesciences.org
The cerebellum is hypothesized to represent timing information important for organizing
salient motor events during periodically performed discontinuous movements. To provide …

How do spike collisions affect spike sorting performance?

S Garcia, AP Buccino, P Yger - Eneuro, 2022 - eneuro.org
Recently, a new generation of devices have been developed to record neural activity
simultaneously from hundreds of electrodes with a very high spatial density, both for in vitro …

Complex spikes perturb movements and reveal the sensorimotor map of Purkinje cells

SZ Muller, JS Pi, P Hage, MA Fakharian… - Current Biology, 2023 - cell.com
Computations that are performed by the cerebellar cortex are transmitted via simple spikes
of Purkinje cells (P-cells) to downstream structures, but because P-cells are many synapses …

Correlated signatures of social behavior in cerebellum and anterior cingulate cortex

SW Hur, K Safaryan, L Yang, HT Blair, SC Masmanidis… - Elife, 2024 - elifesciences.org
The cerebellum has been implicated in the regulation of social behavior. Its influence is
thought to arise from communication, via the thalamus, to forebrain regions integral in the …

[HTML][HTML] Organization of reward and movement signals in the basal ganglia and cerebellum

N Larry, G Zur, M Joshua - Nature Communications, 2024 - nature.com
The basal ganglia and the cerebellum are major subcortical structures in the motor system.
The basal ganglia have been cast as the reward center of the motor system, whereas the …

Xenon LFP analysis platform is a novel graphical user interface for analysis of local field potential from large-scale MEA recordings

A Mahadevan, NK Codadu, RR Parrish - Frontiers in Neuroscience, 2022 - frontiersin.org
High-density multi-electrode array (HD-MEA) has enabled neuronal measurements at high
spatial resolution to record local field potentials (LFP), extracellular action potentials, and …