Tendon and ligament healing and current approaches to tendon and ligament regeneration
NL Leong, JL Kator, TL Clemens… - Journal of …, 2020 - Wiley Online Library
Ligament and tendon injuries are common problems in orthopedics. There is a need for
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …
Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis
E Gracey, A Burssens, I Cambré, G Schett… - Nature reviews …, 2020 - nature.com
Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …
and ligaments require physiological levels of mechanical loading to develop and maintain …
Temporal dynamics and heterogeneity of cell populations during skeletal muscle regeneration
Mammalian skeletal muscle possesses a unique ability to regenerate, which is primarily
mediated by a population of resident muscle stem cells (MuSCs) and requires a concerted …
mediated by a population of resident muscle stem cells (MuSCs) and requires a concerted …
Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration
Many adult tissues contain resident stem cells, such as the Pax7+ satellite cells within
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …
A clinical, biological, and biomaterials perspective into tendon injuries and regeneration
G Walden, X Liao, S Donell, MJ Raxworthy… - … Engineering Part B …, 2017 - liebertpub.com
Tendon injury is common and debilitating, and it is associated with long-term pain and
ineffective healing. It is estimated to afflict 25% of the adult population and is often a career …
ineffective healing. It is estimated to afflict 25% of the adult population and is often a career …
Flexor tendon: development, healing, adhesion formation, and contributing growth factors
Management of flexor tendon injuries of the hand remains a major clinical problem. Even
with intricate repair, adhesion formation remains a common complication. Significant …
with intricate repair, adhesion formation remains a common complication. Significant …
Mechanical regulation of musculoskeletal system development
N Felsenthal, E Zelzer - Development, 2017 - journals.biologists.com
During embryogenesis, the musculoskeletal system develops while containing within itself a
force generator in the form of the musculature. This generator becomes functional relatively …
force generator in the form of the musculature. This generator becomes functional relatively …
Directionality of developing skeletal muscles is set by mechanical forces
Formation of oriented myofibrils is a key event in musculoskeletal development. However,
the mechanisms that drive myocyte orientation and fusion to control muscle directionality in …
the mechanisms that drive myocyte orientation and fusion to control muscle directionality in …
Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling
Mechanical forces between cells and extracellular matrix (ECM) influence cell shape and
function. Tendons are ECM-rich tissues connecting muscles with bones that bear extreme …
function. Tendons are ECM-rich tissues connecting muscles with bones that bear extreme …
Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells
Tendons are highly specialized load-bearing tissues with very limited healing capacity.
Given their mechanosensitive nature, the combination of tendon mimetic scaffolds with …
Given their mechanosensitive nature, the combination of tendon mimetic scaffolds with …