Ligament and tendon injuries are common problems in orthopedics. There is a need for
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …

Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

Mammalian skeletal muscle possesses a unique ability to regenerate, which is primarily
mediated by a population of resident muscle stem cells (MuSCs) and requires a concerted …

Many adult tissues contain resident stem cells, such as the Pax7+ satellite cells within
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …

Tendon injury is common and debilitating, and it is associated with long-term pain and
ineffective healing. It is estimated to afflict 25% of the adult population and is often a career …

Management of flexor tendon injuries of the hand remains a major clinical problem. Even
with intricate repair, adhesion formation remains a common complication. Significant …

During embryogenesis, the musculoskeletal system develops while containing within itself a
force generator in the form of the musculature. This generator becomes functional relatively …

Formation of oriented myofibrils is a key event in musculoskeletal development. However,
the mechanisms that drive myocyte orientation and fusion to control muscle directionality in …

Mechanical forces between cells and extracellular matrix (ECM) influence cell shape and
function. Tendons are ECM-rich tissues connecting muscles with bones that bear extreme …

Tendons are highly specialized load-bearing tissues with very limited healing capacity.
Given their mechanosensitive nature, the combination of tendon mimetic scaffolds with …