Shortening and removal of the 3′ poly (A) tail of mature mRNA by poly (A)-specific 3′
exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation …

Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion
must first be removed from the genome. This process of removing and replacing DNA …

DNA continuously suffers the loss of its constituent bases, and thereby, a loss of potentially
vital genetic information. Sites of missing bases—termed abasic or apurinic/apyrimidinic …

The major human AP endonuclease APE1 (HAP1, APEX, Ref1) initiates the repair of abasic
sites generated either spontaneously, from attack of bases by free radicals, or during the …

Abstract APE1/Ref-1 (hereafter, APE1), a DNA repair enzyme and a transcriptional
coactivator, is a vital protein in mammals. Its role in controlling cell growth and the molecular …

DNA apurinic-apyrimidinic (AP) sites are prevalent noncoding threats to genomic stability
and are processed by AP endonuclease 1 (APE1). APE1 incises the AP-site phosphodiester …

The heterogeneity of most cancers diminishes the treatment effectiveness of many cancer-
killing regimens. Thus, treatments that hold the most promise are ones that block multiple …

In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a
DNA glycosylase‐independent manner, providing the correct ends for DNA synthesis …

Alkylating agents are standard components of adjuvant chemotherapy for gliomas. We
provide evidence here that Ape1/Ref-1, the major mammalian apurinic/apyrimidinic …

Maintenance of genomic integrity is critical for the perpetuation of all forms of life including
humans. Living organisms are constantly exposed to stress from internal metabolic …