The biological responses to dienone compounds with a 1, 5-diaryl-3-oxo-1, 4-pentadienyl
pharmacophore have been studied extensively. Despite their expected general thiol …

We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by
targeting ubiquitin receptor RPN13 within the proteasome's 19S regulatory particle. The …

Bortezomib and the other licensed 20S proteasome inhibitors show robust activity against
liquid tumors like multiple myeloma, but have disappointed against solid tumors including …

Objectives Revascularization is necessary in patients with ischemic stroke, however it does
not address inflammation that contribute to reperfusion injury and the early growth of …

Intestinal ischemic-reperfusion injury (IRI) occurs when vascular blood flow is interrupted in
the mesenteric vessels, followed by reperfusion when blood flow is re-established to the …

Selective killing of cancer cells by chemotherapy has been an age old challenge, but certain
unique features of cancer cells allow discriminatory response between cancer and normal …

C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with
other rings, with one nitrogen atom as the only ring hetero atom and three or more double …