Objective The use of thiazolidinediones (TZDs) has been associated with increased fracture
risk. We performed a comprehensive literature review and meta-analysis to estimate the risk …

Elevated plasma triglyceride (TG) concentrations are associated with an increased risk of
atherosclerotic cardiovascular disease (CVD), hepatic steatosis and pancreatitis. Existing …

Importance Studies suggest pioglitazone use may increase risk of cancers. Objective To
examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 …

Aims To determine whether thiazolidinedione use is associated with a risk of bladder
cancer. Methods We searched MEDLINE and EMBASE in J une 2012 (with P ub M ed …

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of
type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses …

In parallel with the type 2 diabetes pandemic, diabetic kidney disease has become the
leading cause of end-stage renal disease worldwide, and is associated with high …

The safety and usefulness of pioglitazone (Pio) is repeatedly called into question due to the
contradictory information available about it. A meta-analysis and risk benefit assessment …

Owing to the complementary mechanisms of action of metformin hydrochloride (MH) and
pioglitazone hydrochloride (PG), combination therapy for type 2 diabetes mellitus using the …

The administration of pioglitazone as an oral therapy is restricted due to various challenges.
The aim of the current investigation was to evaluate the suitability of pioglitazone in …

There is a concern of an increased risk of bladder cancer associated with the use of
thiazolidinediones, a class of oral glucose-lowering drugs commonly used in patients with …