Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …

Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic
connectivity. The extracellular signals, particularly neuron-derived molecules, that drive …

With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in
regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of …

Alzheimer disease (AD) is the most prevalent neurodegenerative disorder leading to
dementia in the elderly. Unfortunately, no cure for AD is available to date. Increasing …

Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder, which is
characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular …

Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …