New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …

VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …

Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)
thiazolidin-2-ylidene) amino) benzenesulfonamides (4a-m and 7a-g). All the newly prepared …

Herein, a nano-integrated strategy was used to combine an anti-angiogenic agent sorafenib
and a photosensitizer chlorin e6 to form carrier-free multifunctional nanoparticles (SC NPs) …

Herein we report the design and synthesis of novel N-substituted isatins-SLC-0111 hybrids
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …

In the current study, we designed and synthesized a series of new quinoline derivatives 10a-
p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary …

As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates (7, 8a–
c, 9 and 10a–e) is here designed and synthesised with the prime aim to develop more …