Population genetics of malaria resistance in humans

PW Hedrick - Heredity, 2011 - nature.com
The high mortality and widespread impact of malaria have resulted in this disease being the
strongest evolutionary selective force in recent human history, and genes that confer …

The global distribution of the Duffy blood group

RE Howes, AP Patil, FB Piel, OA Nyangiri… - Nature …, 2011 - nature.com
Blood group variants are characteristic of population groups, and can show conspicuous
geographic patterns. Interest in the global prevalence of the Duffy blood group variants is …

Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people

D Ménard, C Barnadas, C Bouchier… - Proceedings of the …, 2010 - National Acad Sciences
Malaria therapy, experimental, and epidemiological studies have shown that erythrocyte
Duffy blood group-negative people, largely of African ancestry, are resistant to erythrocyte …

Defining the global spatial limits of malaria transmission in 2005

CA Guerra, RW Snow, SI Hay - Advances in parasitology, 2006 - Elsevier
There is no accurate contemporary global map of the distribution of malaria. We show how
guidelines formulated to advise travellers on appropriate chemoprophylaxis for areas of …

Reduced Plasmodium vivax Erythrocyte Infection in PNG Duffy-Negative Heterozygotes

LJ Kasehagen, I Mueller, B Kiniboro, MJ Bockarie… - PLoS …, 2007 - journals.plos.org
Background Erythrocyte Duffy blood group negativity reaches fixation in African populations
where Plasmodium vivax (Pv) is uncommon. While it is known that Duffy-negative …

Resistance to malaria in humans: the impact of strong, recent selection

PW Hedrick - Malaria journal, 2012 - Springer
Malaria is one of the leading causes of death worldwide and has been suggested as the
most potent type of selection in humans in recent millennia. As a result, genes involved in …