Abstract First coined by Alexander Sandow in 1952, the term excitation–contraction coupling
(ECC) describes the rapid communication between electrical events occurring in the plasma …

There is an overwhelming body of work supporting the idea that excitation–contraction
coupling in skeletal muscle depends on a physical interaction between the skeletal muscle …

Abstract Store-operated Ca2+ entry (SOCE), a ubiquitous mechanism that allows recovery of
Ca2+ ions from the extracellular space, has been proposed to limit fatigue during repetitive …

Abstract Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle
important for excitation-contraction coupling. Mutations in the RYR1 gene yield RyR1 protein …

The concept of excitation–contraction coupling is almost as old as Journal of General
Physiology. It was understood as early as the 1940s that a series of stereotyped events is …

The excitation–contraction coupling (ECC) in skeletal muscle refers to the Ca2+-mediated
link between the membrane excitation and the mechanical contraction. The initiation and …

The sarcoplasmic reticulum of skeletal muscle cells is a highly ordered structure consisting
of an intricate network of tubules and cisternae specialized for regulating Ca2+ homeostasis …

Calsequestrin, the only known protein with cyclical storage and supply of calcium as main
role, is proposed to have other functions, which remain unproven. Voluntary movement and …

Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks
of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that …

In the last decades the term Store-operated Ca 2+ entry (SOCE) has been used in the
scientific literature to describe an ubiquitous cellular mechanism that allows recovery of …