Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

Many new chemical entities (NCEs) have been discovered with the development of the
pharmaceutical industry. However, the main disadvantage of these drugs is their low …

Although zein is a natural protein derived from corn, it has attracted much interest in
pharmaceutical and biomedical sciences. Recent remarkable investigations on the use of …

Preparation of drug nanoparticles has been studied and evaluated in this study based on
supercritical-based processing as green technology. Computational works have been …

Solubility limited bioavailability is one of the crucial parameters that affect the formulation
development of the new chemical entities. Thus the major constraint in the pharmaceutical …

Although solid dispersions have been reported as an efficient drug delivery system, the
design of specific dosage forms for pharmaceutical therapy is necessary to improve the …

This study aimed to investigate the role of micellization of sodium lauryl sulfate (SLS) in
poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using the anti-solvent …

Valsartan (VAL) is a BCS class II drug with low solubility and high permeability and, thus, its
formulations often encounter low bioavailability problems. Its low bioavailability can be …

Background: An increase in poorly water-soluble drugs makes the design of drug delivery
systems challenging. Methods: Currently, a number of prospective solid dispersions have …

As amorphization may improve the solubility and bioavailability of a drug substance, the aim
of this work was to assess to what extent the crystallinity of caffeine (CAF) and theophylline …