Autophagy in hepatic ischemia–reperfusion injury

B Mao, W Yuan, F Wu, Y Yan, B Wang - Cell death discovery, 2023 - nature.com
Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver resection or liver
transplantation that can seriously affect patient's prognosis. There is currently no definitive …

[HTML][HTML] Mechanistic insight and clinical implications of ischemia/reperfusion injury post liver transplantation

J Liu, K Man - Cellular and molecular gastroenterology and …, 2023 - Elsevier
Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction and graft failure. The mechanism of hepatic …

The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy

D Xu, L Chen, X Chen, Y Wen, C Yu, J Yao, H Wu… - Cell death & …, 2017 - nature.com
Nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidants has been
implicated to have protective roles in ischemia-reperfusion (I/R) injury in many animal …

Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection

C Xie, N Li, H Wang, C He, Y Hu, C Peng, Y Ouyang… - Gut …, 2020 - Taylor & Francis
Helicobacter pylori (H. pylori) infection is the strongest known risk factor for the development
of gastric cancer. DNA damage response (DDR) and autophagy play key roles in …

Extended criteria grafts and emerging therapeutics strategy in liver transplantation. The unstable balance between damage and repair

D Ghinolfi, F Melandro, F Torri, C Martinelli… - Transplantation …, 2021 - Elsevier
Due to increasing demand for donor organs,“extended criteria” donors are increasingly
considered for liver transplantation, including elderly donors and donors after cardiac death …

Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury

W Zhou, Z Zhong, D Lin, Z Liu, Q Zhang, H Xia… - Cell death & …, 2021 - nature.com
Ischemia-reperfusion injury (IRI) is an inevitable and serious clinical problem in donations
after heart death (DCD) liver transplantation. Excessive sterile inflammation plays a fateful …

Dual effect of hepatic macrophages on liver ischemia and reperfusion injury during liver transplantation

TF Lu, TH Yang, CP Zhong, C Shen, WW Lin… - Immune …, 2018 - synapse.koreamed.org
Ischemia-reperfusion injury (IRI) is a major complication in liver transplantation (LT) and it is
closely related to the recovery of grafts' function. Researches has verified that both innate …

Autophagy in cancer therapy—molecular mechanisms and current clinical advances

I Ganzleben, MF Neurath, C Becker - Cancers, 2021 - mdpi.com
Simple Summary Autophagy is the capability of cells to dismantle and recycle parts of
themselves. This process is closely intertwined with other crucial cell functions, such as …

Protective role of mTOR in liver ischemia/reperfusion injury: involvement of inflammation and autophagy

T Zhang, J Guo, J Gu, K Chen, H Li… - Oxidative Medicine and …, 2019 - Wiley Online Library
Liver ischemia/reperfusion (IR) injury is a common phenomenon after liver resection and
transplantation, which often results in liver graft dysfunction such as delayed graft function …

Isoflurane preconditioning alleviated murine liver ischemia and reperfusion injury by restoring AMPK/mTOR-mediated autophagy

Z Rao, X Pan, H Zhang, J Sun, J Li, T Lu… - Anesthesia & …, 2017 - journals.lww.com
BACKGROUND: Isoflurane has a pharmacological preconditioning effect against ischemia
injury in the heart, kidney, and brain, but whether and how isoflurane preconditioning …