This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Sex/gender effects have been demonstrated for multiple aspects of addiction, with one of the
most commonly cited examples being the “telescoping effect” where women meet criteria …

Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

The ventral pallidum (VP) plays a critical role in the processing and execution of motivated
behaviors. Yet this brain region is often overlooked in published discussions of the …

Repeated exposure to drugs of abuse enhances the motor-stimulant response to these
drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from …

Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …

The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …

Extinction is a form of inhibitory learning that suppresses a previously conditioned response.
Both fear and drug seeking are conditioned responses that can lead to maladaptive …

The medial prefrontal cortex (mPFC) is critically involved in numerous cognitive functions,
including attention, inhibitory control, habit formation, working memory and long-term …