Biological biomarkers of oral cancer

A Radaic, P Kamarajan, A Cho, S Wang… - Periodontology …, 2023 - Wiley Online Library
The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally
improved in the last few years, with less than a 1% improvement per year from 2005 to 2017 …

Circulating tumor HPV DNA for surveillance of HPV-positive oropharyngeal squamous cell carcinoma: a narrative review

KAL Kuhs, JC Brenner, FC Holsinger… - JAMA oncology, 2023 - jamanetwork.com
Importance Human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma
has an overall favorable prognosis, yet a subset of patients will experience devastating …

Liquid Biopsies with Circulating Plasma HPV–DNA Measurements—A Clinically Applicable Surveillance Tool for Patients with HPV-Positive Oropharyngeal Cancer

KK Jakobsen, SK Bendtsen, N Pallisgaard… - Clinical Cancer …, 2023 - AACR
Purpose: To evaluate the accuracy of cell-free human papillomavirus-DNA (cfHPV-DNA)
measurements in liquid biopsies in predicting disease in patients with HPV-positive/p16 …

[HTML][HTML] Analytical validation of NavDx, a cfDNA-based fragmentomic profiling assay for HPV-driven cancers

A Gunning, S Kumar, CK Williams, BM Berger… - Diagnostics, 2023 - mdpi.com
The NavDx® blood test analyzes tumor tissue modified viral (TTMV)-HPV DNA to provide a
reliable means of detecting and monitoring HPV-driven cancers. The test has been clinically …

Personalizing surveillance in head and neck cancer

GJ Hanna, N Patel, SG Tedla, KL Baugnon… - American Society of …, 2023 - ascopubs.org
Head and neck squamous cell carcinoma (HNSCC) encompasses a spectrum of
heterogeneous diseases originating in the oral cavity, pharynx, and larynx. Within the United …

Comparing the Diagnostic Performance of Quantitative PCR, Digital Droplet PCR, and Next-Generation Sequencing Liquid Biopsies for Human Papillomavirus …

S Naegele, DA Ruiz-Torres, Y Zhao, D Goss… - The Journal of Molecular …, 2024 - Elsevier
Human papillomavirus (HPV)-associated cancers, including oropharyngeal squamous cell
carcinoma (HPV+ OPSCC), cervical cancer, and squamous cell carcinoma of the anus …

[HTML][HTML] Negative predictive value of circulating tumor tissue modified viral (TTMV)-HPV DNA for HPV-driven oropharyngeal cancer surveillance

GJ Hanna, SA Roof, J Jabalee, EM Rettig… - Clinical Cancer …, 2023 - AACR
Purpose: Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell
carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in …

Tumor-derived exosomes and the role of liquid biopsy in human papillomavirus oropharyngeal squamous cell carcinoma

MM Allevato, JD Smith, MJ Brenner… - The Cancer …, 2023 - journals.lww.com
The global incidence of human papillomavirus–positive (HPV+) head and neck squamous
cell carcinoma (HNSCC) has surged in recent decades, with HPV+ HNSCC accounting for> …

Detection of serum biomarkers of HPV-16 driven oropharynx and oral cavity cancer in Brazil

L Sichero, MG Gonçalves, F Bettoni, EM Coser, G Mota… - Oral Oncology, 2024 - Elsevier
Background HPV-16 driven oropharynx/oral cavity squamous cell carcinomas prevalence
varies globally. We evaluated the presence of HPV-16 ctDNA and HPV-16 E6 antibodies in …

[HTML][HTML] The Clinical Utility of Circulating HPV DNA Biomarker in Oropharyngeal, Cervical, Anal, and Skin HPV-Related Cancers: A Review

IM Andrioaie, I Luchian, C Dămian, G Nichitean… - Pathogens, 2023 - mdpi.com
Human papillomavirus (HPV) is recognized as being related to a wide variety of known
cancers: cervical, oropharyngeal, anal, vaginal, penile, and skin. For some of these cancers …