Rheumatoid arthritis (RA) is a chronic aggressive arthritis that is characterized with systemic
inflammation response, the production of abnormal antibodies, and persistent synovitis. One …

Cytokines are pleiotropic polypeptides that control the development of and responses
mediated by immune cells. Cytokine classification predominantly relies on [1] the target …

Summary Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates immune cell
homeostasis and has been used to treat a range of disorders including cancer and …

Abstract Interleukin-2 (IL-2) is a very well-known cytokine that has been studied for the past
35 years. It plays a major role in the growth and proliferation of many immune cells such NK …

IL-2 is critical for peripheral tolerance mediated by regulatory T (Treg) cells, which represent
an obstacle for effective cancer immunotherapy. Although IL-2 is important for effector (E) T …

Polyfunctionality/multifunctionality of effector T cells at the single cell level has been shown
as an important parameter to predict the quality of T cell response and immunological …

Electrochemical sensors based on antibody-antigen recognition events are commonly used
for the rapid, label-free, and sensitive detection of various analytes. However, various …

Abstract Interleukin-2 (IL-2) is a multifunctional cytokine in immune regulation. It is essential
for the differentiation, expansion and stability of CD25+ Foxp3+ regulatory T (Treg) cells …

The in vivo biological activity of IL-2 can be dramatically increased by complexing with anti-
IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes selectively stimulate different …

Abstract IL-2 and IL-15 are structurally relative cytokines that share two receptor subunits,
CD132 (γ c chain) and CD122 (β chain). However, the expression pattern and physiological …