The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

Epithelial to mesenchymal transition (EMT) is a process that allows an epithelial cell to
acquire a mesenchymal phenotype through multiple biochemical changes resulting in an …

Objectives: To explore the role of the renin–angiotensin–aldosterone system (RAAS) in the
pathogenesis of pulmonary arterial hypertension (PAH) induced by chronic exposure to …

Animal model of cigarette smoke (CS)–induced chronic obstructive pulmonary disease
(COPD) is the primary testing methodology for drug therapies and studies on pathogenic …

Background and Purpose Tetramethylpyrazine (TMP) was originally isolated from the
traditional Chinese herb ligusticum and the fermented Japanese food natto and has since …

Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a
key pathophysiological component of airway remodeling in chronic obstructive pulmonary …

Canonical or classical transient receptor potential channel 6 (TRPC6) is a Ca2+-permeable
non-selective cation channel that is widely expressed in the heart, lung, and vascular …

Aims Previously we demonstrated that both hypoxia inducible factor-1 (HIF-1) and bone
morphogenetic protein-4 (BMP4) up-regulate transient receptor potential canonical (TRPC) …

Chronic obstructive pulmonary disease (COPD) is a major global epidemic with increasing
incidence worldwide. The pathogenesis of COPD is involved with mitochondrial autophagy …