tRNA dysregulation and disease
EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
Epigenetic regulation of human non-coding RNA gene transcription
M Morselli, G Dieci - Biochemical Society Transactions, 2022 - portlandpress.com
Recent investigations on the non-protein-coding transcriptome of human cells have
revealed previously hidden layers of gene regulation relying on regulatory non-protein …
revealed previously hidden layers of gene regulation relying on regulatory non-protein …
Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria
During transcription, the nascent RNA can invade the DNA template, forming extended RNA-
DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase …
DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase …
Chromatin remodeling by Pol II primes efficient Pol III transcription
C Yague-Sanz, V Migeot, M Larochelle… - Nature …, 2023 - nature.com
The packaging of the genetic material into chromatin imposes the remodeling of this barrier
to allow efficient transcription. RNA polymerase II activity is coupled with several histone …
to allow efficient transcription. RNA polymerase II activity is coupled with several histone …
Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation
In eukaryotes, RNA polymerase (RNAP) III transcribes hundreds of genes for tRNAs and 5S
rRNA, among others, which share similar promoters and stable transcription initiation …
rRNA, among others, which share similar promoters and stable transcription initiation …
An RNA polymerase III subunit determines sites of retrotransposon integration
A Bridier-Nahmias, A Tchalikian-Cosson, JA Baller… - Science, 2015 - science.org
Mobile genetic elements are ubiquitous. Their integration site influences genome stability
and gene expression. The Ty1 retrotransposon of the yeast Saccharomyces cerevisiae …
and gene expression. The Ty1 retrotransposon of the yeast Saccharomyces cerevisiae …
Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes
E Leśniewska, M Boguta - Open biology, 2017 - royalsocietypublishing.org
RNA polymerase III (Pol III) transcribes a limited set of short genes in eukaryotes producing
abundant small RNAs, mostly tRNA. The originally defined yeast Pol III transcriptome …
abundant small RNAs, mostly tRNA. The originally defined yeast Pol III transcriptome …
Human cytomegalovirus infection elicits global changes in host transcription by RNA polymerases I, II, and III
How human cytomegalovirus (HCMV) infection impacts the transcription of the host genome
remains incompletely understood. Here, we examine the global consequences of infection …
remains incompletely understood. Here, we examine the global consequences of infection …
RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry
Quiescence is a reversible G0 state essential for differentiation, regeneration, stem-cell
renewal, and immune cell activation. Necessary for long-term survival, quiescent chromatin …
renewal, and immune cell activation. Necessary for long-term survival, quiescent chromatin …
Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III
RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs
(collectively 'Pol III genes') whose early established biological roles were so essential that …
(collectively 'Pol III genes') whose early established biological roles were so essential that …