The major histocompatibility complex (MHC) is one of the most extensively studied regions
in the human genome because of the association of variants at this locus with autoimmune …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases
(IBD) that often involve organs other than those of the gastrointestinal tract. These …

Background & Aims: There are few systematic studies on the natural history or
immunogenetic associations of erythema nodosum (EN) or ocular inflammation in …

NOD2/caspase recruitment domain (CARD) 15 variants are identified in up to 50% of
Crohn's disease (CD) patients. Functional variants of toll-like receptor-4 (TLR4) and CD14 …

Anterior uveitis describes inflammation that involves the iris or ciliary body. Anterior uveitis
may be part of a systemic illness such as a spondyloarthropathy. It may also arise from an …

Diffusely adherent Escherichia coli (DAEC) strains are currently considered to constitute a
putative sixth group of diarrheagenic E. coli. However, on the basis of their diffuse …

Major histocompatibility complex (MHC) class I chain related (MIC) molecules show
homology with classical human leukocyte antigen (HLA) molecules, but they do not combine …

Non-conventional MHC class I MIC molecules interact not with the TCR, but with NKG2D, a
C-type lectin activatory receptor present on most NK, γδ and CD8+ αβ T cells. While this …

Inflammatory bowel disease (IBD) arises in part from a genetic predisposition, through the
inheritance of a number of contributory genetic polymorphisms. These variant forms of …

Linkage and association studies implicate the human leucocyte antigen (HLA) region in
genetic susceptibility to ulcerative colitis (UC). However, associations with specific variants …