The development of drug-resistant bacteria, as well as multidrug-resistant pathogens related
to substantial mortality, is an important global health threat. The wide range of biological …

Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to humanity due to
easy transmission and difficult-to-treat skin and flimsy diseases. The most threatening aspect …

Skeletal editing involves making specific point‐changes to the core of a molecule through
the selective insertion, deletion or exchange of atoms. It thus represents a potentially …

The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

The continuous demand of medicinally important scaffolds has prompted the synthetic
chemists to identify simple and efficient routes for their synthesis. 1H-1, 2, 3-triazole …

An emerging trend in small-molecule pharmaceuticals, generally composed of nitrogen
heterocycles (N-heterocycles), is the incorporation of aliphatic fragments. Derivatization of …

Antibacterial-resistance speaks to an overall alarm, particularly in regards to the flare-up of
methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and …

Bioisosteres provide valuable design elements that medicinal chemists can use to adjust the
structural and pharmacokinetic characteristics of bioactive compounds towards viable drug …

Infectious diseases resulting from various strains of pathogenic bacteria are among the
leading causes of death and morbidity worldwide. The currently-available antibacterial …

As antibiotic-resistant bacteria and genes continue to emerge, the identification of effective
alternatives to traditional antibiotics has become a pressing issue. Antimicrobial peptides …