Chromosome gains are detrimental for the development of the human embryo. As such,
autosomal trisomies almost always result in spontaneous abortion, and the rare embryos …

Trisomy 18 is the second most common aneuploidy syndromes in live born infants. It is
associated with high mortality rates, estimated to be 75%–95% in the first year of life, as well …

The trisomy 18 and trisomy 13 syndromes represent important and common conditions of
human aneusomy. Together, their combined prevalence in live born infants approaches …

Background Congenital heart disease is common in patients with Trisomy 13 (T13) and
Trisomy 18 (T18), but offering cardiac surgery to these patients has been controversial. We …

There has been substantial controversy regarding treatment of congenital heart defects in
infants with trisomies 13 and 18. Most reports have focused on surgical outcomes versus …

Objectives To identify factors associated with prenatal, perinatal, and postnatal outcomes,
and determine medical care use for fetuses and infants with trisomy 13 (T13) and trisomy 18 …

Children with trisomy 13 and 18 (previously deemed “incompatible with life”) are living
longer, warranting a comprehensive overview of their unique comorbidities and complex …

The effects of medical and surgical interventions on the survival of patients with trisomy 18
have been reported, leading to changes in perinatal management and decision‐making …

Importance Causes of death in children with birth defects are poorly understood. Objective
To determine mortality rates by cause of death in children with and without birth defects …

As the care and management of congenital heart disease changed in trisomy 21, so too it
has with trisomy 13 and 18. Physicians and parents should develop goal-directed treatment …