The actions of androgens such as testosterone and dihydrotestosterone are mediated via
the androgen receptor (AR), a ligand-dependent nuclear transcription factor and member of …

This review discusses mechanisms by which progesterone receptors (PR) regulate
transcription. We examine available data in different species and tissues regarding:(1) …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

The androgen receptor (AR) is a key regulator of prostate growth and the principal drug
target for the treatment of prostate cancer. Previous studies have mapped AR targets and …

High androgen receptor (AR) level in primary tumour predicts increased prostate cancer‐
specific mortality. However, the mechanisms that regulate AR function in prostate cancer are …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

Prostate cancer treatment is dominated by strategies to control androgen receptor (AR)
activity. AR has an impact on prostate cancer development through the regulation of not only …

The pioneering factor FOXA1 opens chromatin to facilitate androgen receptor (AR) binding
to prostate-specific genes. How FOXA1 controls the AR cistrome, however, is incompletely …

The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it
functions is unclear. Here, using chromatin immunoprecipitation coupled to massively …

Despite advances in detection and therapy, castration-resistant prostate cancer continues to
be a major clinical problem. The aberrant activity of stem cell pathways, and their regulation …