Bacterial antibiotic resistance: the most critical pathogens

G Mancuso, A Midiri, E Gerace, C Biondo - Pathogens, 2021 - mdpi.com
Antibiotics have made it possible to treat bacterial infections such as meningitis and
bacteraemia that, prior to their introduction, were untreatable and consequently fatal …

Treatment options for K. pneumoniae, P. aeruginosa and A. baumannii co-resistant to carbapenems, aminoglycosides, polymyxins and tigecycline: an approach …

S Karakonstantis, EI Kritsotakis, A Gikas - Infection, 2020 - Springer
The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

Mechanisms of antibiotic resistance in important gram-positive and gram-negative pathogens and novel antibiotic solutions

L Kakoullis, E Papachristodoulou, P Chra, G Panos - Antibiotics, 2021 - mdpi.com
Multidrug-resistant bacteria have on overwhelming impact on human health, as they cause
over 670,000 infections and 33,000 deaths annually in the European Union alone. Of these …

Emergent polymyxin resistance: end of an era?

Z Li, Y Cao, L Yi, JH Liu, Q Yang - Open forum infectious …, 2019 - academic.oup.com
Until recently, the polymyxin antibiotics were used sparingly due to dose limiting toxicities.
However, the lack of therapeutic alternatives for infections caused by highly resistant Gram …

Treatment Outcomes of Colistin- and Carbapenem-resistant Acinetobacter baumannii Infections: An Exploratory Subgroup Analysis of a Randomized Clinical Trial

Y Dickstein, J Lellouche… - Clinical Infectious …, 2019 - academic.oup.com
Background We evaluated the association between mortality and colistin resistance in
Acinetobacter baumannii infections and the interaction with antibiotic therapy. Methods This …

Fosfomycin as partner drug for systemic infection management. A systematic review of its synergistic properties from in vitro and in vivo studies

RM Antonello, L Principe, AE Maraolo, V Viaggi, R Pol… - Antibiotics, 2020 - mdpi.com
Fosfomycin is being increasingly prescribed for multidrug-resistant bacterial infections. In
patients with systemic involvement, intravenous fosfomycin is usually administered as a …

A new method for the electrostatic manipulation of droplet movement by triboelectric nanogenerator

X Sun, Y Feng, B Wang, Y Liu, Z Wu, D Yang, Y Zheng… - Nano Energy, 2021 - Elsevier
In view of the limitations of the current water droplet manipulation technology in liquid
environment, a new polyaniline and polyvinylidene fluoride nanowire-based triboelectric …

Cefiderocol: a novel Siderophore cephalosporin against multidrug‐resistant gram‐negative pathogens

JC Abdul‐Mutakabbir, S Alosaimy… - … : The Journal of …, 2020 - Wiley Online Library
Cefiderocol (CFDC),(formerly S‐649266), is a novel injectable siderophore cephalosporin
developed by Shionogi & Co., Ltd., with potent in vitro activity against Gram‐negative …

Colistin-Resistant Acinetobacter Baumannii Bacteremia: A Serious Threat for Critically Ill Patients

G Papathanakos, I Andrianopoulos, A Papathanasiou… - Microorganisms, 2020 - mdpi.com
The prevalence of acinetobacter baumannii (AB) as a cause of hospital infections has been
rising. Unfortunately, emerging colistin resistance limits therapeutic options and affects the …

Rescued chlorhexidine activity by resveratrol against carbapenem-resistant Acinetobacter baumannii via down-regulation of AdeB efflux pump

U Singkham-In, PG Higgins, DL Wannigama… - PLoS …, 2020 - journals.plos.org
The aim of this study was to determine the activity and synergistic mechanisms of resveratrol
in combination with chlorhexidine against carbapenem-resistant Acinetobacter baumannii …