Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Liver cirrhosis is a chronic disease that affects the liver structure, protein expression, and
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …

The purpose of the present study was to examine simultaneously the absolute protein
amounts of 152 membrane and membrane‐associated proteins, including 30 metabolizing …

The blood–brain barrier (BBB) maintains brain homeostasis by tightly regulating the
exchange of molecules with systemic circulation. It consists primarily of microvascular …

The dissolution, intestinal absorption and presystemic metabolism of a drug depend on its
physicochemical characteristics but also on numerous physiological (eg gastrointestinal pH …

Protein expression levels of drug-metabolizing enzymes and transporters in human jejunal
tissues excised from morbidly obese subjects during gastric bypass surgery were evaluated …

Protein quantification data on drug metabolizing enzymes and transporters (collectively
referred as DMET proteins) in human tissues are useful in predicting interindividual …

Recently, it has become evident that pharmaceutical excipients may interfere with the activity
of ATP-binding cassette (ABC) transporters and solute carriers (SLC). The present review …

The intestinal epithelium represents a natural barrier against harmful xenobiotics, while
facilitating the uptake of nutrients and other substances. Understanding the interaction of …