Ultra‐high dose rate dosimetry: challenges and opportunities for FLASH radiation therapy

F Romano, C Bailat, PG Jorge, MLF Lerch… - Medical …, 2022 - Wiley Online Library
The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …

A potential revolution in cancer treatment: A topical review of FLASH radiotherapy

Y Gao, R Liu, CW Chang, S Charyyev… - Journal of Applied …, 2022 - Wiley Online Library
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …

A novel proton pencil beam scanning FLASH RT delivery method enables optimal OAR sparing and ultra-high dose rate delivery: a comprehensive dosimetry study for …

S Wei, H Lin, JI Choi, CB Simone, M Kang - Cancers, 2021 - mdpi.com
Simple Summary This study attempts to answer a novel and clinically relevant question of
the value of Bragg-peak-based FLASH planning for lung tumors. Most existing studies and …

A roadmap to clinical trials for FLASH

PA Taylor, JM Moran, DA Jaffray… - Medical …, 2022 - Wiley Online Library
While FLASH radiation therapy is inspiring enthusiasm to transform the field, it is neither new
nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials …

Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo

L Karsch, J Pawelke, M Brand, S Hans… - Radiotherapy and …, 2022 - Elsevier
Background and purpose Continuing recent experiments at the research electron
accelerator ELBE at the Helmholtz-Zentrum Dresden-Rossendorf the influence of beam …

Spread‐out Bragg peak proton FLASH irradiation using a clinical synchrocyclotron: proof of concept and ion chamber characterization

A Darafsheh, Y Hao, X Zhao, T Zwart… - Medical …, 2021 - Wiley Online Library
Purpose The purpose of this work is to (a) demonstrate the feasibility of delivering a spread‐
out Bragg peak (SOBP) proton beam in ultra‐high dose rate (FLASH) using a proton therapy …

[HTML][HTML] Framework for quality assurance of ultrahigh dose rate clinical trials investigating FLASH effects and current technology gaps

W Zou, R Zhang, E Schüler, PA Taylor… - International Journal of …, 2023 - Elsevier
Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …

Demonstration of momentum cooling to enhance the potential of cancer treatment with proton therapy

V Maradia, D Meer, R Dölling, DC Weber, AJ Lomax… - Nature Physics, 2023 - nature.com
In recent years, there has been a considerable push towards ultrahigh dose rates in proton
therapy to effectively utilize motion mitigation strategies and potentially increase the sparing …

Response of diamond detectors in ultra-high dose-per-pulse electron beams for dosimetry at FLASH radiotherapy

R Kranzer, A Schüller, A Bourgouin… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. With increasing investigation of the so-called FLASH effect, the need for accurate
real time dosimetry for ultra-high dose rates is also growing. Considering the ultra-high dose …

[HTML][HTML] FLASH radiotherapy using single-energy proton PBS transmission beams for hypofractionation liver cancer: Dose and dose rate quantification

S Wei, H Lin, JI Choi, C Hajj, CB Simone… - Frontiers in …, 2022 - frontiersin.org
Purpose This work aims to study the dose and ultra-high-dose rate characteristics of
transmission proton pencil beam scanning (PBS) FLASH radiotherapy (RT) for …