AHR in the intestinal microenvironment: safeguarding barrier function
Mammalian aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that
belongs to the basic helix–loop–helix (bHLH)–PAS family of transcription factors, which are …
belongs to the basic helix–loop–helix (bHLH)–PAS family of transcription factors, which are …
Toxicities of polycyclic aromatic hydrocarbons for aquatic animals
M Honda, N Suzuki - International journal of environmental research and …, 2020 - mdpi.com
Polycyclic aromatic hydrocarbons (PAHs) are organic compounds that are widely distributed
in the air, water, and soil. Recently, the amount of PAHs derived from fuels and from …
in the air, water, and soil. Recently, the amount of PAHs derived from fuels and from …
Polyaromatic hydrocarbons (PAHs) in the water environment: A review on toxicity, microbial biodegradation, systematic biological advancements, and environmental …
M Vijayanand, A Ramakrishnan, R Subramanian… - Environmental …, 2023 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are considered a major class of organic
contaminants or pollutants, which are poisonous, mutagenic, genotoxic, and/or …
contaminants or pollutants, which are poisonous, mutagenic, genotoxic, and/or …
Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer
R Stading, G Gastelum, C Chu, W Jiang… - Seminars in cancer …, 2021 - Elsevier
Lung cancer has the second highest incidence and highest mortality compared to all other
cancers. Polycyclic aromatic hydrocarbon (PAH) molecules belong to a class of compounds …
cancers. Polycyclic aromatic hydrocarbon (PAH) molecules belong to a class of compounds …
[HTML][HTML] A compendium of mutational signatures of environmental agents
Summary Whole-genome-sequencing (WGS) of human tumors has revealed distinct
mutation patterns that hint at the causative origins of cancer. We examined mutational …
mutation patterns that hint at the causative origins of cancer. We examined mutational …
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Background High tumor mutational burden (TMB) is an emerging biomarker of sensitivity to
immune checkpoint inhibitors and has been shown to be more significantly associated with …
immune checkpoint inhibitors and has been shown to be more significantly associated with …
Why are there hotspot mutations in the TP53 gene in human cancers?
The p53 gene contains homozygous mutations in~ 50–60% of human cancers. About 90%
of these mutations encode missense mutant proteins that span~ 190 different codons …
of these mutations encode missense mutant proteins that span~ 190 different codons …
Mutational signatures associated with tobacco smoking in human cancer
Tobacco smoking increases the risk of at least 17 classes of human cancer. We analyzed
somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking …
somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking …
Polycyclic aromatic hydrocarbons: from metabolism to lung cancer
B Moorthy, C Chu, DJ Carlin - Toxicological Sciences, 2015 - academic.oup.com
Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer,
a disease with the highest cancer mortality in the United States. After entry into the lung …
a disease with the highest cancer mortality in the United States. After entry into the lung …
[HTML][HTML] Lack of exercise is a major cause of chronic diseases
FW Booth, CK Roberts, MJ Laye - Comprehensive physiology, 2012 - ncbi.nlm.nih.gov
Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause
of most chronic diseases. The initial third of the article considers: activity and prevention …
of most chronic diseases. The initial third of the article considers: activity and prevention …