Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …

Dynamic changes in circulating and tissue metabolites and lipids occur in response to
exercise-induced cellular and whole-body energy demands to maintain metabolic …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied …

Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue
(WAT), has reached pandemic proportions and acts as a primer for a wide range of …

Targeted proteomics enables hypothesis-driven research by measuring the cellular
expression of protein cohorts related by function, disease, or class after perturbation. Here …

Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones
that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces …

Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs
have been met and its nutrient storage has reached capacity. As these sphingolipids accrue …

A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …

Degradation and recycling of plasma membrane proteins occurs via the endolysosomal
system, wherein endosomes bud into the cytosol from the plasma membrane and …