Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is
becoming recognized as key modulators of signal transduction pathways with a …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

The endocannabinoid system (ECS) is composed of the endocannabinoid ligands
anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors …

Since COPD is a heterogeneous disease, a specific anti-inflammatory therapy for this
disease has not been established yet. Oxidative stress is recognized as a major …

Exposure to hypoxia increases pulmonary vascular resistance, leading to elevated
pulmonary arterial pressure and, potentially, right heart failure. Vascular remodeling is an …

Colon cancer cells, like other types of cancer cells, undergo the remodeling of the
intracellular Ca 2+ homeostasis that contributes to cancer cell hallmarks including enhanced …

The human TRP protein family comprises a family of 27 cation channels with diverse
permeation and gating properties. The common theme is that they are very important …

Canonical or classical transient receptor potential channel 6 (TRPC6) is a Ca2+-permeable
non-selective cation channel that is widely expressed in the heart, lung, and vascular …

Hyperproliferation of pulmonary arterial smooth muscle cells is a key component of vascular
remodeling in the setting of pulmonary hypertension (PH). Numerous studies have explored …