Macrophages as tools and targets in cancer therapy
A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
A guide to complement biology, pathology and therapeutic opportunity
DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies
Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …
Neutrophil diversity and plasticity in tumour progression and therapy
Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …
embryonic and organ development, as well as cancer progression. Genome-wide …
Diversity, mechanisms, and significance of macrophage plasticity
M Locati, G Curtale, A Mantovani - Annual Review of Pathology …, 2020 - annualreviews.org
Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …
Complosome—the intracellular complement system
EE West, C Kemper - Nature Reviews Nephrology, 2023 - nature.com
The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …
self-derived antigens. Complement is traditionally known as a serum-effective system …
Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
CD10+ GPR77+ cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness
S Su, J Chen, H Yao, J Liu, S Yu, L Lao, M Wang… - Cell, 2018 - cell.com
Carcinoma-associated fibroblasts (CAFs) are abundant and heterogeneous stromal cells in
tumor microenvironment that are critically involved in cancer progression. Here, we …
tumor microenvironment that are critically involved in cancer progression. Here, we …
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
Mitotic cell division increases tumour mutation burden and copy number load, predictive
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …