Unlocking G-quadruplexes as antiviral targets
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
[HTML][HTML] The biogenesis, mechanism and function of the tRNA-derived small RNA (tsRNA): a review compared with microRNA
Y Zhao, X Li, C Ye, C Huang, X Lv… - American journal of cancer …, 2023 - ncbi.nlm.nih.gov
Since the discovery of the first miRNA in 1993, numerous studies have focused on their
biogenesis, their functions on regulating a diversity of cellular processes, and the molecular …
biogenesis, their functions on regulating a diversity of cellular processes, and the molecular …
Unravelling roles of error-prone DNA polymerases in shaping cancer genomes
Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse
underlying mutagenic mechanisms that shape cancer genomes are not understood. This …
underlying mutagenic mechanisms that shape cancer genomes are not understood. This …
Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt's lymphoma
t (8; 14) translocation is the hallmark of Burkitt's lymphoma and results in c-MYC
deregulation. During the translocation, c-MYC gene on chromosome 8 gets juxtaposed to …
deregulation. During the translocation, c-MYC gene on chromosome 8 gets juxtaposed to …
Characterization of G-quadruplex antibody reveals differential specificity for G4 DNA forms
Accumulating evidence suggests that human genome can fold into non-B DNA structures,
when appropriate sequence and favourable conditions are present. Among these, G …
when appropriate sequence and favourable conditions are present. Among these, G …
Characterization of G4 DNA formation in mitochondrial DNA and their potential role in mitochondrial genome instability
S Dahal, H Siddiqua, VK Katapadi, D Iyer… - The FEBS …, 2022 - Wiley Online Library
Mitochondria possess their own genome which can be replicated independently of nuclear
DNA. Mitochondria being the powerhouse of the cell produce reactive oxygen species, due …
DNA. Mitochondria being the powerhouse of the cell produce reactive oxygen species, due …
Chromatin ubiquitination Guides DNA double strand break signaling and repair
KG Kolobynina, A Rapp, MC Cardoso - Frontiers in Cell and …, 2022 - frontiersin.org
Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …
nucleus. The initial chromatin structure at the site of the DNA damage determines both …
Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics
N Kumari, H Antil, S Kumari, SC Raghavan - Genomics, 2023 - Elsevier
Ligase IV is a key enzyme involved during DNA double-strand breaks (DSBs) repair through
nonhomologous end joining (NHEJ). However, in contrast to Ligase IV deficient mouse cells …
nonhomologous end joining (NHEJ). However, in contrast to Ligase IV deficient mouse cells …
[HTML][HTML] EpCAM-mediated cellular plasticity promotes radiation resistance and metastasis in breast cancer
A substantial number of breast cancer (BC) patients undergoing radiation therapy (RT)
develop local recurrence over time. During RT therapy, cells can gradually acquire …
develop local recurrence over time. During RT therapy, cells can gradually acquire …
Block Copolymer Encapsulation of Disarib, an Inhibitor of BCL2 for Improved Chemotherapeutic Potential
A chemical inhibitor of antiapoptotic protein, BCL2, known as Disarib, suffers poor solubility
in aqueous environments; thereby limiting its potential as a chemotherapeutic agent. To …
in aqueous environments; thereby limiting its potential as a chemotherapeutic agent. To …