Infants born prematurely are at high risk to develop white matter injury (WMI), due to
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …

Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …

Elucidating brain cell type specific gene expression patterns is critical towards a better
understanding of how cell-cell communications may influence brain functions and …

Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …

Recent advances in genetic manipulation have greatly expanded our understanding of
cellular responses to platelet-derived growth factors (PDGFs) during animal development. In …

The developmental process of myelination and the adult regenerative process of
remyelination share the common objective of investing nerve axons with myelin sheaths. A …

Myelinating oligodendrocytes arise from migratory and proliferative oligodendrocyte
progenitor cells (OPCs). Complete myelination requires that oligodendrocytes be uniformly …

Oligodendrocytes are the myelinating cells of the central nervous system that constitute
about 5 to 10% of the total glial population. These cells are responsible for myelin sheath …

Activation of purinoceptors by extracellular ATP is an important component of the glial
response to injury in the central nervous system (CNS). ATP has been shown to evoke …

Perinatal white matter injury (WMI) is the most common brain injury in premature infants and
can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically …