Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Faecalibacterium: a bacterial genus with promising human health applications

R Martín, D Rios-Covian, E Huillet… - FEMS Microbiology …, 2023 - academic.oup.com
In humans, many diseases are associated with alterations in gut microbiota, namely
increases or decreases in the abundance of specific bacterial groups. One example is the …

Targeting the gut microbiota for cancer therapy

MR Fernandes, P Aggarwal, RGF Costa… - Nature Reviews …, 2022 - nature.com
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

[HTML][HTML] Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

K Nie, K Ma, W Luo, Z Shen, Z Yang, M Xiao… - Frontiers in cellular …, 2021 - frontiersin.org
Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated
bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent …

The microbial landscape of colorectal cancer

MT White, CL Sears - Nature Reviews Microbiology, 2024 - nature.com
Colorectal cancer (CRC) is a substantial source of global morbidity and mortality in dire
need of improved prevention and treatment strategies. As our understanding of CRC grows …

[HTML][HTML] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Hot and cold tumors: Immunological features and the therapeutic strategies

L Wang, H Geng, Y Liu, L Liu, Y Chen, F Wu, Z Liu… - MedComm, 2023 - Wiley Online Library
Abstract The “hotness” or “coldness” of the tumors are determined by the information of the
cancer cells themselves, tumor immune characteristics, tumor microenvironment, and …

[HTML][HTML] Machine learning approaches in microbiome research: challenges and best practices

G Papoutsoglou, S Tarazona, MB Lopes… - Frontiers in …, 2023 - frontiersin.org
Microbiome data predictive analysis within a machine learning (ML) workflow presents
numerous domain-specific challenges involving preprocessing, feature selection, predictive …

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity

Y Choi, JN Lichterman, LA Coughlin, N Poulides… - Science …, 2023 - science.org
Gut microbiota, specifically gut bacteria, are critical for effective immune checkpoint
blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment …

[HTML][HTML] Intratumor microbiome in cancer progression: current developments, challenges and future trends

J Liu, Y Zhang - Biomarker Research, 2022 - Springer
Cancer is a complicated disease attributed to multifactorial changes, which causes
difficulties with treatment strategies. Various factors have been regarded as the main …