In recent decades, in silico absorption, distribution, metabolism, excretion (ADME), and
toxicity (T) modelling as a tool for rational drug design has received considerable attention …

Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

P-Glycoprotein (Pgp) is one of the best characterized ABC transporters, often involved in the
multidrug-resistance phenotype overexpressed by several cancer cell lines. Experimental …

P-glycoprotein (P-gp) the multidrug transporter is a well-characterised member of the super-
family of ATP-binding cassette (ABC) transporters, and mediates the clearance of xenotoxins …

The impact of P-glycoprotein (P-gp) on the multidrug resistance and pharmacokinetics of
clinically important drugs has been widely recognized. Here, we review in silico approaches …

P-glycoprotein (P-gp) actively transports a wide variety of chemically diverse compounds out
of cells. It is highly associated with the ADMET properties of drugs and drug candidates and …

Drug carriers tailored to fit the physicochemical properties of anticancer agents and the
therapeutic peculiarities of tumor management are envisioned for improving the …

While oral exposure continues to be the major focus, the chemical space of recent drug
discovery is apparently trending towards more hydrophilic libraries, due to toxicity and drug …

Background Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide
range of biological and medicinal properties including anti-inflammatory activity. Therefore …