The biology of aging is challenging to study, particularly in humans. As a result, model
organisms are used to approximate the physiological context of aging in humans. However …

Sporadic breast cancer develops through the accumulation of molecular abnormalities in
normal breast tissue, resulting from exposure to estrogens and other carcinogens beginning …

A primary function of DNA methylation in mammalian genomes is to repress transposable
elements (TEs). The widespread methylation loss that is commonly observed in cancer cells …

The spatial organization of the genome is enigmatic. Direct evidence of physical contacts
between chromosomes and their visualization at nanoscale resolution has been limited. We …

The mechanical properties of cells change with their differentiation, chronological age, and
malignant progression. Consequently, these properties may be useful label-free biomarkers …

Aging is associated with tissue-level changes in cellular composition that are correlated with
increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor …

Age is the greatest risk factor for breast cancer, but the reasons underlying this association
are unclear. While there is undeniably a genetic component to all cancers, the accumulation …

The human breast parenchyma consists of collecting ducts and terminal duct lobular units
(TDLUs). The TDLU is the site of origin of most breast cancers. The reason for such focal …

Immortality is an essential characteristic of human carcinoma cells. We recently developed
an efficient, reproducible method that immortalizes human mammary epithelial cells (HMEC) …

Abstract RNA polymerase III (Pol III) transcribes medium-sized non-coding RNAs
(collectively termed Pol III genes). Emerging diverse roles of Pol III genes suggest that …