Arthropod promoters for genetic control of disease vectors

J Wudarski, S Aliabadi, M Gulia-Nuss - Trends in Parasitology, 2024 - cell.com
Vector-borne diseases (VBDs) impose devastating effects on human health and a heavy
financial burden. Malaria, Lyme disease, and dengue fever are just a few examples of VBDs …

Systems for Targeted Silencing of Gene Expression and Their Application in Plants and Animals

DM Motorina, YA Galimova, NV Battulina… - International Journal of …, 2024 - mdpi.com
At present, there are a variety of different approaches to the targeted regulation of gene
expression. However, most approaches are devoted to the activation of gene transcription …

Potent GST Ketosteroid Isomerase Activity Relevant to Ecdysteroidogenesis in the Malaria Vector Anopheles gambiae

Y Musdal, A Ismail, B Sjödin, B Mannervik - Biomolecules, 2023 - mdpi.com
Nobo is a glutathione transferase (GST) crucially contributing to ecdysteroid biosynthesis in
insects of the orders Diptera and Lepidoptera. Ecdysone is a vital steroid hormone in …

Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito

BC Poulton, F Colman, A Anthousi… - PLOS Neglected …, 2024 - journals.plos.org
Insecticide resistance is a serious threat to our ability to control mosquito vectors which
transmit pathogens including malaria parasites and arboviruses. Understanding the …

An efficient and safe strategy for germ cell‐specific automatic excision of foreign DNA in F1 hybrid transgenic silkworms

D Long, R Liu, Y Huang, A Fu, Y Zhang, Z Hao… - Insect …, 2024 - Wiley Online Library
The safety of transgenic technology is a major obstacle in the popularization and use of
transgenic silkworms and their products. In sericulture, only the first filial generation (F1) …

Site-directed φC31-mediated integration and cassette exchange in Anopheles vectors of malaria

A Adolfi, A Lynd, GJ Lycett, AA James - JoVE (Journal of Visualized …, 2021 - jove.com
Functional genomic analysis and related strategies for genetic control of malaria rely on
validated and reproducible methods to accurately modify the genome of Anopheles …

Transposon and Transgene Tribulations in Mosquitoes: A Perspective of piRNA Proportions

NC Lau, VM Macias - DNA, 2024 - mdpi.com
Mosquitoes, like Drosophila, are dipterans, the order of “true flies” characterized by a single
set of two wings. Drosophila are prime model organisms for biomedical research, while …

Transgenic Manipulation of Arthropod Vectors: Tools to Study Vector-Borne Diseases

AE Williams, KE Olson - JoVE (Journal of Visualized Experiments), 2023 - jove.com
Blood-feeding arthropods such as mosquitoes, ticks, and sandflies transmit several
medically relevant pathogens, many of which are understudied and lack adequate …

Characterizing insecticide resistance mechanisms in mosquitoes using genetic modification and a rapid automated larval resistance detection assay

B Poulton - 2021 - archive.lstmed.ac.uk
Insecticide resistance is a threat to malaria and arbovirus control programmes targeting
mosquito vectors. Integrated control programmes which include control of larval stages are …

Transposon-Based Technologies for Insects

DA O'Brochta - Transgenic Insects: Techniques and …, 2022 - cabidigitallibrary.org
Insect science has benefited greatly from the variety of technologies created from
transposons since their first use to develop germline transformation technology in the early …