Recent perspective of polymeric biomaterial in tissue engineering–a review

MUA Khan, MA Aslam, MFB Abdullah, A Hasan… - Materials Today …, 2023 - Elsevier
Tissue engineering represents an advanced approach to treating patients who have
suffered tissue or organ loss or failure, with the ultimate goals of tissue restoration and …

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

JA Ortega, GP Soares de Aguiar… - Wiley …, 2024 - Wiley Online Library
The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …

Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids

P Saglam-Metiner, U Devamoglu, Y Filiz… - Communications …, 2023 - nature.com
The bioengineerined and whole matured human brain organoids stand as highly valuable
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …

Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity

P Saglam-Metiner, E Yildirim, C Dincer, O Basak… - Microchimica Acta, 2024 - Springer
The complex structure and function of the human central nervous system that develops from
the neural tube made in vitro modeling quite challenging until the discovery of brain …

Biosensor integrated brain-on-a-chip platforms: progress and prospects in clinical translation

B Cecen, E Saygili, I Zare, O Nejati, D Khorsandi… - Biosensors and …, 2023 - Elsevier
Because of the brain's complexity, developing effective treatments for neurological disorders
is a formidable challenge. Research efforts to this end are advancing as in vitro systems …

Differentiation of neurons, astrocytes, oligodendrocytes and microglia from human induced pluripotent stem cells to form neural tissue-on-chip: a neuroinflammation …

P Saglam-Metiner, E Duran, L Sabour-Takanlou… - Stem Cell Reviews and …, 2024 - Springer
Advances in stem cell (SC) technology allow the generation of cellular models that
recapitulate the histological, molecular and physiological properties of humanized in vitro …

Constructing Tumor Organoid-like Tissue for Reliable Drug Screening Using Liver-Decellularized Extracellular Matrix Scaffolds

Z Chen, L Long, J Wang, W Li, A Wang, RK Kankala… - ACS …, 2024 - ACS Publications
The interplay between cells and their microenvironments plays a pivotal role in in vitro drug
screening. Creating an environment that faithfully mimics the conditions of tumor cells within …

Bioinspired microstructures through decellularization of plants for tissue engineering applications

Y Arslan, A Paradiso, N Celiktas, T Erdogan… - European Polymer …, 2023 - Elsevier
In nature, various patterns such as branches, stripes, spirals, and hexagons exist in
biological and natural systems, from nano-to macro-scale. These hierarchical structures …

Comprehensive transcriptomic investigation of Rett syndrome reveals increasing complexity trends from induced pluripotent stem cells to neurons with implications for …

YC Odabasi, S Yanasik, P Saglam-Metiner… - ACS …, 2023 - ACS Publications
Rett syndrome (RTT) is a rare genetic neurodevelopmental disorder that has no cure apart
from symptomatic treatments. While intense research efforts are required to fulfill this unmet …

The Application of Biomaterial‐Based Spinal Cord Tissue Engineering

L Ma, Z Zhang, Y Mu, B Liu, H Zhou… - Macromolecular …, 2024 - Wiley Online Library
Advancements in biomaterial‐based spinal cord tissue engineering technology have
profoundly influenced regenerative medicine, providing innovative solutions for both spinal …