Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

Klotho is a membrane‐bound or soluble antiaging protein, whose protective activity is
essential for a proper function of many organs. In 1997, an accidental insertion of a …

Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal
plants that are reputed for a variety of pharmacological effects. Both as an active principle of …

Rapid advancements have taken place in gene therapy technology. However, effective
methods for treating aging-or age-related chronic diseases, which are often closely related …

Alzheimer's disease (AD) is the most common type of senile dementia. The antiaging gene
Klotho is reported to decline in the brain of patients and animals with AD. However, the role …

Sphingolipids (SLs) play a significant role in the nervous system, as major components of
the myelin sheath, contributors to lipid raft formation that organize intracellular processes, as …

Recurrent seizures in epilepsy may lead to progressive neuronal damage, which can
diminish health-related quality of life. Evaluation and control of pathological processes in the …

Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid
precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the …