Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable
transcriptional silencing. PcG proteins participate in distinct multimeric complexes that …

Recent transcriptome analyses show that substantial proportions of eukaryotic genomes can
be copied into RNAs, many of which do not encode protein sequences. However, cells have …

A large fraction of the mammalian genome is organized into inactive chromosomal domains
along the nuclear lamina. The mechanism by which these lamina associated domains …

Repetitive sequences account for more than 50% of the human genome.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease …

Polycomb group genes (PcG) encode a group of about 16 proteins that were first identified
in Drosophila as repressors of homeotic genes. PcG proteins are present in all metazoans …

Regulation of transcription is a tightly choreographed process. The establishment of RNA
polymerase II promoter proximal pausing soon after transcription initiation and the release of …

A long-standing mystery in the field of Polycomb and Trithorax regulation is how these
proteins, which are highly conserved between flies and mammals, can regulate several …

Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic
repression of key developmental regulatory genes. PcG proteins are recruited to specific …

The Hippo pathway regulates growth through the transcriptional coactivator Yorkie, but how
Yorkie promotes transcription remains poorly understood. We address this by characterizing …

Abstract The Drosophila GAGA factor (GAF) is a multifunctional protein implicated in
nucleosome organization and remodeling, activation and repression of gene expression …