A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds

S Anwar, S Khan, A Almatroudi, AA Khan… - Molecular Biology …, 2021 - Springer
Advanced glycation end products (AGEs) are naturally occurring biomolecules formed by
interaction of reducing sugars with biomolecules such as protein and lipids etc., Long term …

Current biomedical use of copper chelation therapy

S Baldari, G Di Rocco, G Toietta - International journal of molecular …, 2020 - mdpi.com
Copper is an essential microelement that plays an important role in a wide variety of
biological processes. Copper concentration has to be finely regulated, as any imbalance in …

[HTML][HTML] Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

X Wang, X Chen, W Zhou, H Men, T Bao, Y Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy
(DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a …

6‐Gingerol alleviates Ferroptosis and inflammation of diabetic cardiomyopathy via the Nrf2/HO‐1 pathway

S Wu, J Zhu, G Wu, Z Hu, P Ying, Z Bao… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Diabetes mellitus (DM) can induce cardiomyocyte injury and lead to diabetic
cardiomyopathy (DCM) which presently has no specific treatments and consequently …

Inflammatory mechanisms in the pathophysiology of diabetic peripheral neuropathy (DN)—new aspects

P Baum, KV Toyka, M Blüher, J Kosacka… - International Journal of …, 2021 - mdpi.com
The pathogenesis of diabetic neuropathy is complex, and various pathogenic pathways
have been proposed. A better understanding of the pathophysiology is warranted for …

Antioxidant activity of sulfur and selenium: a review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms

EE Battin, JL Brumaghim - Cell biochemistry and biophysics, 2009 - Springer
It is well known that oxidation caused by reactive oxygen species (ROS) is a major cause of
cellular damage and death and has been implicated in cancer, neurodegenerative, and …

Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

S Brings, T Fleming, M Freichel… - International journal of …, 2017 - mdpi.com
Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid
adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is …

The role of zinc and copper in insulin resistance and diabetes mellitus

G Bjørklund, M Dadar, L Pivina… - Current medicinal …, 2020 - ingentaconnect.com
The prevalence of Type 2 Diabetes Mellitus (T2DM) is internationally ever-growing.
Therefore, prevention, diagnostics, and control of insulin resistance and T2DM are of …

Nutritional and functional properties of gluten-free flours

A Culetu, IE Susman, DE Duta, N Belc - Applied Sciences, 2021 - mdpi.com
This study characterized and compared 13 gluten-free (GF) flours (rice, brown rice, maize,
oat, millet, teff, amaranth, buckwheat, quinoa, chickpea, gram, tiger nut, and plantain) for …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …