Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that overlap in their clinical presentation, pathology and …

Autophagy is a complicated cellular mechanism that maintains cellular and tissue
homeostasis and integrity via degradation of senescent, defective subcellular organelles …

Senile osteoporosis (OP) is often concomitant with decreased autophagic activity. OPTN
(optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor …

Macroautophagy/autophagy is a highly conserved process in eukaryotic cells. It plays a
critical role in cellular homeostasis by delivering cytoplasmic cargos to lysosomes for …

Autophagy is a highly conserved protein degradation pathway from yeasts to humans that is
essential for removing protein aggregates and misfolded proteins in healthy cells. Recently …

Studies over the past two decades have led to major advances in the pathogenesis of
Paget's disease of bone (PDB) and particularly on the role of genetic factors. Germline …

Degenerative diseases affecting the nervous and skeletal systems affect the health of
millions of elderly people. Optineurin (OPTN) has been associated with numerous …

Glaucoma is one of the leading causes of bilateral blindness, affecting nearly 57 million
people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells …

Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by
increased osteoclast-mediated bone resorption and a subsequent compensatory increase in …

Multisystem proteinopathy (MSP) is a pleiotropic group of inherited disorders that cause
neurodegeneration, myopathy, and bone disease, and share common pathophysiology …